I have several USB2Serial devices and used them on several laptops from win98 to win10.
On win7 there's no problem if you use old drivers and old cables. If you update the driver it may happen that formerly working cables turn into a dysfunctional 15 EUR piece of junk.
On win8 and win10 the old chips won't work. You'll need a new cable and the latest driver's .
In a nutshell: Profilic did that to make counterfeit chipsets worthless.
Here's a checktool which chipset you have: http://www.prolific.com.tw/US/ShowProdu ... 25&pcid=41
As far as I know FTDI did the same, but I have no details on that.